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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.

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Pragmatic is a software developer that provides a variety of casino games available on online gambling platforms. Pragmatic's iGaming software is used by top operators as well as land-based casinos. The company offers front-end tools for design, analysis, promotions, marketing payment systems, security, customer service and bug reporting. In addition, the company provides its players a safe and secure environment that features high-quality graphics and games.

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A pragmatic trial that uses a variety investigators and includes participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, that is crucial for pragmatic trials to be valid and lessen the chance of bias is also essential. However too much heterogeneity could result in issues with the design of the trial.

Pragmatic Play is also a major player on the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta provide customers with an authentic gambling experience, and a wide range of virtual betting options. The company also offers a variety of games that make online gambling exciting and interactive. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.

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Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software is designed to work with mobile devices and supports multiple languages. Despite its relatively young age it has established itself as a leading casino gaming platform. The latest releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually requested by practitioners and policymakers to inform their decisions. They are also a good method of determining the causality between an intervention and its results. However, they should not be used to substitute for the use of explanation trials.

The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the clinical or physiological hypothesis as well as pragmatic trials, which inform the practice and policy decisions. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as monitoring.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.