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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use of standard equipment.

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A practical trial that employs various investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid, and it also helps reduce bias in the results. However too much heterogeneity could result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers a variety of classic table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic experience in gambling and a wide variety of betting options via virtual. The company also has created various interactive games to make gambling online enjoyable. Some of these shows are broadcast live, while others include famous people from the industry.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically ordered by policymakers and practitioners in order to inform their decisions. They can also be a great method of determining the causality between an intervention and its results. However, they shouldn't be used as a substitute for the use of explanation trials.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study, including recruitment, design, implementation of the intervention, and follow-up.

There is a positive increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary-care settings.