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Pragmatic trials are trials designed to inform the practice of clinical trials in real life. They are typically described as focusing on practical aspects of design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and participants from different geographic areas. This kind of heterogeneity, that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. However excessive heterogeneity could result in issues with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and to achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to guide their decisions. They also provide a useful method to determine the cause-effect relationship between the intervention and its effects. They should, however, not be used to replace explanatory studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, 프라그마틱 슬롯 하는법 design, delivery of the intervention and its follow-up.

There is a growing increase in the number of pragmatic trials published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatism. It is important to note that the majority of these studies were conducted in primary-care settings.