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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually focused on the practical aspects of study design, including the recruitment and consent process in adherence, as well as the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be valid and reduce bias in results is also essential. Too much heterogeneity, however could cause issues with the design of the trial.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually commissioned by policymakers and practitioners to guide their decisions. They also provide a useful method to determine the cause-effect relationship between an intervention and its results. However, they shouldn't be used to substitute for the use of explanation trials.

The concept of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study, including the recruitment, design, and delivery of the intervention and 프라그마틱 무료게임 follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of these studies were conducted in primary care settings.