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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically characterized by a focus on practical aspects of the study design, including recruitment and consent in adherence, as well as the use of routinely available equipment.

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Pragmatic is a software company, offers a variety of casino games for online gambling platforms. Pragmatic's iGaming solutions are utilized by the most reputable operators as well as casinos with a physical location. The company provides front-end site design tools, analysis and marketing, promotions security payment systems, customer service, and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.

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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be valid and helps reduce the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

Pragmatic Play, one of the biggest players on the live casino market offers various classic table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta offer customers an authentic experience in gambling as well a full variety of betting options via virtual. The company has also created several interactive game shows to make online gambling fun. Some of these shows are telecast live and some are hosted by famous personalities from the industry.

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Pragmatic Play is renowned for its top-notch games, and for providing a superior user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. It has been recognized as one of the top gaming platforms for casinos despite its relative youth. The latest releases include Wolves which is a five-reel video slot with a healthy RTP and impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are typically requested by practitioners and policymakers in order to guide their decisions. They also provide a useful way to identify the causal relationship between an intervention and its results. However, they should not be used to replace explanatory studies.

The concept of pragmatism is controversial, and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which prove the physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a practical study, including recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) resulted in 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority of these studies were conducted in primary care settings.