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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study that include recruitment and consent, adherence and the use routinely available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity that is crucial for a pragmatic trial to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity, can cause problems with the design of the trial.

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The aim of pragmatic trials is to replicate real-life scenarios and to achieve maximum credibility externally. They are usually requested by policy makers and practitioners to guide their decision-making. They can also be used to determine the causality of an intervention with its outcomes. However, they should not, be used to replace the need for explanation studies.

The pragmatism idea is controversial and there are concerns about whether pragmatic trials should replace or complement them. Schwartz and 프라그마틱 추천 이미지 (published on www.eediscuss.com) Lellouch1 suggested an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool attempted to define the features of a pragmatic study that include the recruitment process, the design and implementation of the intervention, and follow-up.

There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of studies were conducted in primary-care settings.